Major League Baseball stands as the first NES baseball game to be officially licensed by Major League Baseball. Another feature of the game is that each of the 26 teams in 1987 has a line-up reflecting the actual rosters of each team represented.

There are no actual player names due to the lack of a Major League Baseball Players Association endorsement, but such marquee players of the time as Nolan Ryan of the Astros and Dale Murphy of the Braves are represented by their numbers, abilities, throwing arm, and placement in the batting order. Speaking of rosters, Major League Baseball also allows you to change your batting order around, pinch-hit, substitute pitchers, etc. You can take your favorite team to the World Series in the season mode and even play an All-Star game. ~ Christopher Michael Baker, All Game Guide