While little is known about the actual plot line of Resident Evil 5 the current ad campaign is offering a major plot spoiler.   The spoilerific ad can be found in the latest issue of Famitsu, but we can expect similar ads to pop-up in US publications within the next few months.  Gamepro has provided an actual scan of the Famitsu run ad:

     While this may not be a big spoiler for the actual game, as we'll probably be informed of this early on, it is a big spoiler for the RE universe.  Or maybe this is all a fakeout from Capcom just to mess with us.  Who knows?  People at Capcom.  That's who.